It’s the items guru and below that suffer more since a 1 week break, for example, increases the Apprentice intervals by up to 700% but the Guru 2 interval by only 50%.
For a real vacation, stop lessons 2 weeks before to clear out your apprentice queue before starting vacation mode.
However, doing that without vacation mode but just stopping lessons is also a good way to tackle a big review queue so the point stands.