You should give it a try, I would say that it’s not that hard, it’s more that it’s very dense and because of the increased density you get less context to guide you. Sometimes I would struggle to figure out who was talking to whom for instance.
I would say that 鋼の錬金術師 was harder than this when it comes to pure Japanese vocab/grammar. But also you would have pages and pages of action with very little said. That basically never happens in a 4koma.
With 4koma you really need to take your time to analyze every cell because, due to the constraints of the format, a lot is crammed it very little space, both in terms of text but also drawings.
To give you an idea here’s me trying to break down a particularly tricky strip in our 紡ぐ club:
This is a rather extreme example but you can see how there’s a lot happening in not a whole lot of space and you sometimes need to infer a lot of context.