What does this で mean?

In the top right panel after “JOJO”

definition 4 on jisho. It’s just like a conjugation


Its a natural transition marker. Like “well” or “let’s see” in English.

“Blah blah blah, well, anyway, Blah blah blah”

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What manga is this? Looks like I could tackle it.

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for me it is another way to say “well” like in では and short way じゃ

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jojo bizarre adventure

great manga, this one since part 5 I am watching the anime with JP subtitles. It is not difficult to follow the dialogue and you can reinforce kanji and vocab from previous levels.